TYPICAL USAGE:

Indomethacin is used to relieve pain, swelling, and joint stiffness caused by arthritis, gout, bursitis, and tendonitis. It is also used to relieve pain from various other conditions. This medication is known as a non-steroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling and pain. This medication may also be used to relieve pain caused by inflammation of the pouch surrounding the heart and other conditions, as prescribed by your doctor.

SIDE EFFECTS:

Get immediate medical attention if you experience chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, and feeling short of breath. Stop using indomethacin and inform your doctor if you have changes in your vision shortness of breath (even with mild exertion) swelling or rapid weight gain the first sign of any skin rash, no matter how mild signs of stomach bleeding-bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds liver problems-nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes) kidney problems-little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath low red blood cells (anaemia)-pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating or severe skin reaction-fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

DRUG INTERACTION:

• Indomethacin+adefovir- Talk to your doctor before using adefovir together with indomethacin. Adefovir may cause kidney problems, and combining it with other medications that can also affect the kidney such as indomethacin may increase that risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
• Indomethacin+ardeparin- Talk to your doctor before using ardeparin together with indomethacin. Combining these medications can increase the risk of bleeding complications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
• Indomethacin+cidofovir- Using cidofovir together with indomethacin is not recommended. Cidofovir may cause kidney damage, and combining it with other medications that can also affect the kidney such as indomethacin may increase that risk. If you have been receiving indomethacin, you may need to wait at least seven days after your last dose before you can start treatment with cidofovir.
• Indomethacin+desirudin- Using desirudin together with indomethacin may increase the risk of bleeding, including severe and sometimes fatal haemorrhage. Talk to your doctor if you have any questions or concerns.

MECHANISM OF ACTION:

Indomethacin belongs to a group of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). It works by reducing chemicals that cause inflammation and pain in the body.