What is Bartter Syndrome?
Bartter syndrome is a rare inherited congenital defect that affects the kidneys. Bartter syndrome is caused by genetic mutations. Bartter syndrome is of two types - Neonatal Bartter syndrome and classic Bartter syndrome.
Neonatal Bartter syndrome starts before birth. It can be very serious, even life threatening. Babies may not grow as they should in the womb, or they may be born too early. Classic Bartter syndrome usually starts in early childhood and isn't as severe as the antenatal form. But it can affect growth and cause developmental delays.
The Bartter syndrome means that your kidneys are unable to reabsorb Sodium and you lose it in urine. If you have Bartter syndrome, you are likely to have hypokalemia or low potassium level, alkalosis or increased pH value of blood and low blood pressure.
Although another disorder called Gitelman syndrome is closely associated, it is milder than Bartter syndrome.
The main effects of the Bartter syndrome are loss of Sodium in urine, rise in the level of aldosterone hormone, potassium wasting (excessive removal of Potassium from the body), hypokalemic alkalosis (abnormal acid balance in blood), and loss of Calcium in urine.
What are the symptoms of Bartter syndrome?
In most cases, neonatal Bartter syndrome happens during the twenty-fourth to thirtieth week of gestation with polyhydramnios or excessive amniotic fluid. Because of this, the infant will have condition known as polyuria or excessive urination and polydipsia or excessive consumption of fluids. If the infant does not receive requisite quantities of fluids, the complications could be life-threatening. Although these symptoms begin at the first two years after birth, they are most likely diagnosed only after the child is in schooling age.
Symptoms of Bartter syndrome include:
- Growth failure - Rate of weight gain is much lower than that of other children of similar age and gender
- Low blood pressure
- Kidney stones
- Muscle cramping and weakness
- Higher urination frequency
What is the cost for the treatment of Bartter syndrome in India?
Which specialty of doctor is to be consulted for the treatment of Bartter syndrome in India?
Which hospital is to be preferred for the treatment of Bartter syndrome in India?
1. What are the causes of Bartter syndrome?
Genes carry instructions that help your body work right. Genetic diseases can happen when there's a change in the gene (called a mutation).
At least five genes are linked to Bartter syndrome, and they all play an important role in how your kidneys work especially in your ability to take in salt. Losing too much salt through pee (salt wasting) can affect how your kidneys take in other substances, including potassium and calcium.
A lack of balance in these elements can lead to serious problems:
- Too little salt can cause dehydration, constipation, and frequent peeing
- Too little calcium can weaken bones and cause frequent kidney stones
- Low blood levels of potassium can cause muscle weakness, cramping, and fatigue
2. What are the risk factors of Bartter syndrome?
3. What are the possible ways to prevent Bartter syndrome?
- There are no known prevention methodologies for Bartter syndrome, because the disease results from mutations of the genes.
4. How is Bartter syndrome diagnosed?
- Most kidney-related issues cause blood pressure, but Bartter syndrome causes low blood pressure. The above-mentioned symptoms could happen in people who take too many diuretics and laxatives. Medanta - The Medicity hospital in India, Bartter syndrome is diagnosed mainly by using blood tests and urine tests.
5. How is Bartter syndrome treated?