• Test Code - PL0012
  • Test Name - 17-hydroxyprogesterone (17-OHP)
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Test Details & Preparation

Test details and preparation:

  • 17-OH progesterone is an important hormone produced by adrenal glands.The body uses certain enxymes and 17-OH progesterone to make up cortisol,which redspond to stress and flight0fight response.
  • When the enzymes can be produces then the level of 17-OH progesterone increases in the blood.
  • High levels of 17-OH progesterone can indicate a condition called congenital adrenal hyperplasia (CAH),where the production of male sex hormone androgens is increased.
  • The test is routinely ordered to newborns as part of their regular check up and in case of adult when they start to show certain CAH symptoms.
  • In infant/young adults it is ordered when-
  • Listlessness, lack of energy (lethargy)
  • Not eating well
  • Dehydration
  • Low blood pressure
  • Sex organs that are not clearly male or female (ambiguous genitalia)
  • Development of male secondary sex characteristics (virilization)
  • Acne
  • In case of adult women it is ordered when they show-
  • Excess facial and body hair (hirsutism)
  • Lack of or irregular menstrual periods (menses)
  • Development of male secondary sex characteristics
  • Infertility
  • In case of young boy or adults when they show-
  • early onset of puberty, beginning as early as age 2 or 3
  • a deep voice
  • well-defined muscles
  • a large penis and small testes
  • infertility
  • The test is done by taking a blood sample from the vein by inserting a needle into the vein by applying pressure through rubber band.
  • For the preparation of the test doctor may ask to fast for eight hours before the test in case adult or young person. And in case of women the test can be preferred in a specific period during their menstrual cycle.

Results:

  • The normal range for 17-OH progesterone can be-
  • newborns: 1,000-3,000 nanograms/deciliter (ng/dL)
  • babies older than 24 hours: less than 100 ng/dL
  • adults: less than 200 ng/dL
  • Higher 17-OH progesterone value may be the indication of CAH disease or sometimes it can also indicate adrenal tumor for which the hormone level is affected.
  • Lower level may indicate a person is responding=g to treatment and a higher level indicate that the treatment needs to be changed.


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